Combined L-/T-Type Calcium Channel Blockers
نویسندگان
چکیده
منابع مشابه
Combined L-/T-type calcium channel blockers: ready for prime time.
Opening of the voltage-dependent Ca 2 channels permits influx of Ca across the plasma membrane, triggering diverse physiological processes. These channels are widely distributed in the cardiovascular system, constituting the main route for Ca entry essential for excitation and contraction. Ten unique 1 subunits, grouped in 3 families (CaV1, CaV2, and CaV3), that encode the low-voltage– activate...
متن کاملComparative effects of selective T- and L-type calcium channel blockers in the remnant kidney model.
We have previously reported that the dihydropyridine L-type calcium channel blockers (CCBs) have an adverse impact on glomerulosclerosis (GS) in the remnant kidney model despite significant blood pressure (BP) reduction, because of the concurrent deleterious effects on renal autoregulation. The effects of the CCB mibefradil, which is approximately 10-fold more selective for T- than L-type chann...
متن کاملThe role of calcium channel blockers in wound healing
Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors. Calcium channel blockers belong to cardiovascular medicine and administrated to treatment of hypertension, angina and cardiac arrhythmia because of vasodilatory...
متن کاملEffect of Calcium Channel Blockers on Intraocular Pressure in Rabbits
The objective of the study was to evaluate the antiglaucoma effect of calcium channel blockers diltiazem and verapamil. Albino rabbits were used and chronic glaucoma was induced in them using freshly prepared 150 units of alphachymotrypsin. 0.1 mL of drug solution was administered topically into the left eye whereas the right served as control. The pressure recording was carried out at 15, 30, ...
متن کامل61: Calcium Channel Blockers
In 1964, Albretch Fleckenstein described an inhibitory action ofverapamil and prenylamine on excitation-contraction coupling that was similar to calcium depletion. By the late 1970s, the clinical use of calcium channel blockers (CCBs) was widely accepted for variety of cardiovascular indications, including hypertension, dysrhythmias, and angina. Later indications, including Raynaud phenomenon, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 2009
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.108.127548